IP3KA siRNA h, shRNA and Lentiviral Particle Gene Silencers

Gene Stat Angle Cell Pvalue Qvalue A1BG 1.07177295114858

The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. ITPKA gene body displayed low or absent levels of methylation in most normal tissue but was significantly methylated in malignant tumors. In lung cancer, ITPKA gene body methylation first appeared at the in situ carcinoma stage and progressively increased after invasion. Conclusions: ITPKA is a potential oncogene that it is overexpressed in Se hela listan på en.wikipedia.org 2021-03-02 · ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis; ITPKA gene body methylation regulates its expression and serves as a novel and potential biomarker for early cancer detection ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and Metabolism .

IP3-kinase A, MGC:28924 Feature Type. protein coding gene. IDs. MGI Inositol-triphosphate 3-kinase A gene (ITPKA) gene body methylation serves as a potential diagnostic biomarker for early cancer detection. (A) Methylation levels of ITPKA gene body in cancer cell lines (pink), immortalized nonmalignant cell lines (yellow) and primary normal cells (light blue), respectively. Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer.

ITPKA Gene inositol-trisphosphate 3-kinase A Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4.

IP3KA siRNA h, shRNA and Lentiviral Particle Gene Silencers

Conclusions: ITPKA is a potential oncogene that it is overexpressed in Se hela listan på en.wikipedia.org 2021-03-02 · ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis; ITPKA gene body methylation regulates its expression and serves as a novel and potential biomarker for early cancer detection ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and Metabolism . Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity .

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Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases… Expand Compare & Order ITPKA plasmids, CDNA clones, ORF clones and more genomics products. Wide variety of Top suppliers High-quality customer support. NCBI RefSeq genes, predicted subset (XM_* or XR_*) XM_011521522.2 at chr15:41494358-41503555 NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.92) ITPKA at chr15:41493874-41503551 RefSeq Genes ITPKA at chr15:41493874-41503551 - (NM_002220) inositol-trisphosphate 3-kinase A Non-Human RefSeq Genes ITPKA gene product. IP3-3KA, IP3KA.
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Curated assertions on the My Cancer Genome website are housed within a Knowledge Management System (KMS) created through a partnership with GenomOncology that serves as a warehouse of biomarker, disease, and drug ontologies; biomarker-driven cancer clinical trials; therapeutic, prognostic, and diagnostic assertions; and … The C-terminal part of ITPKB, namely residues 187 to 462, was 68% identical to ITPKA in amino acid sequence. Mapping By in situ hybridization, Erneux et al. (1992) mapped the ITPKB gene to 1q41-q43. Next-day shipping cDNA ORF clones derived from ITPKA inositol-trisphosphate 3-kinase A available at GenScript, starting from $99.00. The ITPKC gene provides instructions for making one version (isoform) of the inositol 1,4,5-trisphosphate 3-kinase (ITPK) enzyme.

doi: 10.1073/pnas.1418468112. The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release Daniel J. Apiccoa,b,1 , Evgeny Shlevkova, Catherine L. Nezicha , David T. Trana , Edward Guilmettec, Gene ID: Human(3706) Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling.
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En distinkt molekylär profil associerad med mucinös epithelial

(1992) used in situ hybridization to map the ITPKA gene to 15q14-q21. REFERENCES Erneux, C., Roeckel, N., Takazawa, K., Mailleux, P., Vassart, G., Mattei, M. G. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. Functional Associations. ITPKA has 3,320 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 82 datasets. RefSeq summary [ITPKA] Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol Gene: Itpka - ENSRNOG00000005284 - Rattus norvegicus (rat) General information. Ensembl ID: ENSRNOG00000005284: Name: Itpka: Description Summaries for ITPKA gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Predicted to have inositol hexakisphosphate kinase activity.

Instructions A 1 Additional file 1 - Genes differentially regulated by

Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is ITPKB. ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis; ITPKA gene body methylation regulates its expression and serves as a novel and potential biomarker for early cancer detection ITPKA is one of three inositol-trisphosphate 3-kinase (ITP3K) genes in humans.

ITPKA - Explore an overview of ITPKA, with a histogram displaying coding mutations, full tabulated details of all associated variants, … The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. Gene information about ENSG00000137825 / ITPKA - inositol-trisphosphate 3-kinase A Itpka MGI Mouse Gene Detail - MGI:1333822 - inositol 1,4,5-trisphosphate 3-kinase A. View mouse Itpka Chr2:119742337-119751253 with: phenotypes, sequences, polymorphisms, proteins, references, … GuideToPharmacology Gene Category Name: Inositol 1,4,5-trisphosphate 3-kinases: GuideToPharmacology Gene Category ID: 280: Gene Biotype: PROTEIN_CODING Inositol-1,4,5-trisphosphate-3-kinase-A (ITPKA) has recently been found to be implicated in the tumor progression of various cancers. However, the expression and the prognostic value of ITPKA in hepatocellular carcinoma (HCC) remains unexplored. The aim of this study is to investigate the clinical significance of ITPKA expression in HCC. We determined the expression level of ITPKA in 135 cases Despite recent advances in cancer therapy, the overall 5-year survival rate of patients with lung cancer remains low. The aim of our study was to sear… Functional Associations.